Ddr1 breast cancer
WebA cytokine array was performed to evaluate differences in the breast cancer cell secretome when Sdc1 is silenced. Results: Silencing expression of Sdc1 in breast cancer cells significantly reduced metastasis to the brain. Conversely, overexpression of Sdc1 increased metastasis to the brain. WebDec 13, 2024 · Of note, DDR1 has been shown to be involved in reactivation after dormancy 34 and has been identified as part of a tumor cell quiescence signature 35, 36 that predicted dormancy and late relapse...
Ddr1 breast cancer
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WebFeb 2, 2016 · IGF-I causes DDR1 protein upregulation in breast cancer cells. The study was conducted on MCF-7, and MDA-MB-231 human breast cancer cells. Both these … WebPPI network revealed that COL3A1 showed a significant association with DDR1. Ambrogio et al. reported that DDR1 could be a therapeutic target for KRAS-driven non-small-cell lung cancer [Citation 44]. Another primary …
WebDec 29, 2024 · Studies indicate that DDR1 or DDR2 overexpression has a positive correlation with poor prognosis of cancer patients. 10 For example, DDR1 and DDR2 are highly expressed in invasive ductal breast cancer, 35 and the expression levels of DDR1 and DDR2 are significantly related to advanced TNM stage and lymph node metastasis. … WebApr 23, 2024 · Some studies have shown that fibroblasts account for 70 to 90% of the whole tumor volume of breast cancer and pancreatic cancer 88, 89, 90. More importantly, fibroblasts play a central role...
WebSep 27, 2024 · DDR1 inhibition suppresses tumor growth in vivo by enhancing antitumor T cell activity. Structurally, DDR1 consists of an ECD, a transmembrane domain and an intracellular kinase domain ( 37 … WebNon-integrin collagen receptor discoidin domain receptor-1 (DDR1) expression and p38 MAPK activation are attenuated in α5 (IV)-ablated luminal breast cancer cells, resulting in the reduced c-Myc oncogene expression and phosphorylation.
WebOct 25, 2024 · Study of mesothelioma and lung cancer cells has also suggested that the collagen receptor discoidin domain 1 (DDR1)-mediated upregulation of connective tissue growth factor (CTGF) and early growth response 1 (EGR1) upon IGF-I stimulation requires both IGF-IR and GPER ( 59 ). NF-κB Pathway
WebFeb 16, 2016 · In this study, we set out to evaluate whether IGF-I stimulation may affect DDR1 expression. Indeed, in breast cancer cells (MCF-7 and MDA-MB-231) IGF-I induced significant increase of DDR1 protein expression, in a time and dose dependent manner. However, we did not observe parallel changes in DDR1 mRNA. arif indra irawanWebDec 10, 2024 · DDR1, which is a type of signaling protein called a receptor tyrosine kinase, is overproduced in some breast tumors, which suggests that it could be a potential target for treatment, the researchers explained. arifin djauhariWebNov 5, 2024 · Now, researchers have identified a key molecule, discoidin domain receptor 1 (DDR1), that prevents immune cells from entering tumors and killing the cancer cells inside through the formation of... arifin dwi saputroWebNov 8, 2024 · Researchers have isolated a key molecule, termed discoidin domain receptor 1 (DDR1), which blocks immune cells from entering breast tumors and destroying the cells inside in triple negative breast cancer (TNBC). Identification of DDR1 could open doors for new treatments of this aggressive form of breast cancer. arifindo adiputra ariagunaWebFeb 3, 2024 · During the last decade, immunotherapy has radically changed perspectives on anti-tumor treatments. However, solid tumor treatment by immunotherapy has not met expectations. Indeed, poor clinical response to treatment has highlighted the need to understand and avoid immunotherapy resistance. Cholangiocarcinoma (CCA) is the … arifin evaluasi pembelajaranWebRole of stromal discoidin domain receptor-1 (DDR1) in breast cancer. Abstract: San Antonio Breast Cancer Symposium, 2016. Publication … arifin djakasaputra google scholarWebJul 8, 2024 · Neutrophil extracellular traps (NETs) are a neutrophil-generated extracellular network of chromatin and chromatin-bound molecules with antimicrobial potency. Recent data suggest that NETs are associated with cancer progression and cancer-associated hypercoagulability. Pancreatic adenocarcinoma (PDAC) is a lethal type of cancer in … arifin firdaus bank mandiri