Lineage specifiers
Nettet4. okt. 2013 · Lastly, the lineage specifiers depicted as pluripotency rivals, such as GATA3 and PAX6, have been identified to be able to restore pluripotency in somatic cells. Based on these discoveries, we should reconsider the definitions of pluripotency and lineage specification and present a novel perspective for understanding the … Nettet16. jul. 2013 · A general feature of lineage-specifying transcription factors is that they act to promote their own lineage, but repress alternative fates. This is known to also apply for the transcription...
Lineage specifiers
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Nettet23. mai 2013 · Induction of Pluripotency in Mouse Somatic Cells with Lineage Specifiers. Previous Article Integrative Clinical Genomics of Advanced Prostate Cancer. Next … Nettet12. sep. 2016 · Recent studies show that lineage specifiers play an important role in orchestrating the process of restoring pluripotency by replacing pluripotency-associated transcription factors. Moreover, a combination of small molecules enables the acquisition of pluripotency from somatic cells without any transgenes, offering a tractable platform …
Nettet3. okt. 2013 · Recently, lineage specifiers have been identified to play important roles in orchestrating the process of restoring pluripotency. In this review, we summarize the … Nettet18. aug. 2016 · del Sol and colleagues propose a gene-regulatory network model of stem cell differentiation, and develop a computational method for predicting cell-fate determinants. Experimental validation of predicted cell-fate determinants, ESR1 and RUNX2, confirm that they induce neuronal and astrocyte differentiation from mouse …
Nettet13. sep. 2016 · The Method Predicted Known Lineage Specifiers Even when Differentiation Is Incomplete. The method was also applied to the dataset of CPC differentiation, in which hESCs were differentiated into MESP1 + and MESP1 − (pre-)CPCs (den Hartogh et al., 2015), where only the former was able to differentiate further into … Nettet14. sep. 2015 · Candidate lineage specifiers are identified in three steps. First, a transcriptional regulatory network (TRN) is inferred using single-cell gene expression data, literature knowledge and ...
Nettet16. okt. 2024 · Lineage Specifiers in Lung Cancer Are Ahead of Their TIME. The factors that shape the distinctive tumor-immune landscapes of various types and subtypes of …
Nettet28. mai 2013 · Background Ethanol is a toxin responsible for the neurodevelopmental deficits of Fetal Alcohol Spectrum Disorders (FASD). Recent evidence suggests that ethanol modulates the protein expression of lineage specifier transcription factors Oct4 (Pou5f1) and Sox2 in early stages of mouse embryonic stem (ES) cell differentiation. … how are ipad screen size measuredhow are iphone screens measuredNettet16. jan. 2015 · For years, pluripotency-associated factors and their rivals, lineage specifiers, have been generally considered to determine the identities of pluripotent and differentiated cells, respectively. how are ipers benefits calculatedNettet23. mai 2013 · Here, we report that, during mouse somatic cell reprogramming, pluripotency can be induced with lineage specifiers that are pluripotency rivals to … how are iphones shippedNettet16. okt. 2024 · Lineage Specifiers in Lung Cancer Are Ahead of Their TIME The factors that shape the distinctive tumor-immune landscapes of various types and subtypes of cancer remain poorly understood. In this issue of Immunity, Mollaoglu et al., 2024 how are iphones transportedNettet23. mai 2013 · Here, we identified eight lineage specifiers as OCT4 substitutes, including GATA3, GATA6, and SOX7, which are involved in mesendodermal (ME) lineage … how are ipods different from phonesNettetLineage Conversion - an overview ScienceDirect Topics Lineage Conversion Add to Mendeley About this page Regenerative Therapies for Digestive, Respiratory and Urinary Tissues David L. Stocum, in Regenerative Biology and Medicine (Second Edition), 2012 4 Bone Marrow and Umbilical Cord Blood Cells how are iphones made step by step list