Tmem97 and nash

Author: csqd

August undefined, 2024

WebJan 28, 2024 · TMEM97 has a role in cholesterol and lipid metabolism 10, 11, 12, and it was reported that TMEM97 and cholesterol biosynthesis genes in normal ovarian epithelial cells were coordinately... WebAlthough the sigma-2 receptor was identified as a separate pharmacological entity from the sigma-1 receptor in 1990, the gene that codes for the receptor was identified as TMEM97 …

(PDF) TMEM Proteins in Cancer: A Review - ResearchGate

WebOverview Product name Anti-TMEM97 antibody Description Rabbit polyclonal to TMEM97 Host species Rabbit Tested applications Suitable for: WB, IHC-P more details Species reactivity Reacts with: Human Immunogen antigen sequence: FEDFSKASGFKGQRPETLHERLT, corresponding to amino acids 120-142 of Human … christoph hess

(PDF) Sigma-2 Receptor Ligand Binding Modulates

WebTMEM97 (transmembrane protein 97 or protein MAC30) is a member of IGFBP/insulin-like growth factor-binding protein family and is implicated in several biological processes wherein it acts through its regulatory effects on IGF activity. WebThe gene view histogram is a graphical view of mutations across TMEM97. These mutations are displayed at the amino acid level across the full length of the gene by default. Restrict the view to a region of the gene by dragging across the histogram to highlight the region of interest, or by using the sliders in the filters panel to the left. WebJun 1, 2024 · TMEM97 silencing allowed the authors to conclude that it is involved in the cellular cholesterol homeostasis and, thus, they claimed that TMEM97 is a SREBP protein (sterol regulatory element binding protein) that may regulate the LDL cholesterol transport-regulating protein Niemann-Pick C1 (NPC1) [21]. Later, it was described that TMEM97 ... christoph hess dressage

TMEM97 Gene - GeneCards SGMR2 Protein SGMR2 Antibody

WebJan 28, 2024 · Recently the sigma-2 receptor was identified as transmembrane protein 97 (TMEM97). Progesterone receptor membrane component 1 (PGRMC1) was also recently reported to form a complex with TMEM97 and the low density lipoprotein (LDL) receptor, and this trimeric complex is responsible for the rapid internalization of LDL. WebTMEM97 (MAC30) protein expression summary. Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cancer ce lls 1.Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation 2, 3.Under investigation for its potential … christoph hesse architectsTMEM97 mRNA expression in wildtype and TMEM97−/− mice was examined by reverse transcription PCR (RT-PCR). Total RNA was extracted from four retinas of TMEM97−/− or wildtype mice with the RNeasy kit (Qiagen, Germantown, MD). cDNA was synthesized using 2 µg total RNA as the template and poly … See more All procedures involving animals complied with the ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines and adhered to the ARVO (Association for Research in Vision and Ophthalmology) … See more Wildtype mice (C57Bl/6) were purchased from Jackson Labs (Bar Harbor, ME). TMEM97−/− mice (Tmem97tm1(KOMP)Vlcg, stock # 050147-UCD) were … See more ERGs were recorded with an UTAS system (LKC Technologies, Gaithersburg, MD). Animals were anesthetized with intraperitoneal … See more For retinal histology, animals were killed by CO2 overdose and immediately followed by vascular perfusion with mixed aldehydes53,54. Eyes were collected and embedded in an Epon/Araldite mixture. Semi-thin sections … See more christoph hesshaimer

"WebAug 1, 2024 · Previously, the membrane protein TMEM97 has been identified as an NPC1-interacting protein and regulator of cellular cholesterol levels [26].Decreased TMEM97 levels result in enhanced NPC1 protein levels, along with restored cholesterol transport and decreased lipid accumulation in NPC in vitro models [27].Despite these significant … " - Tmem97 and nash

(PDF) TMEM Proteins in Cancer: A Review - ResearchGate

(PDF) Sigma-2 Receptor Ligand Binding Modulates

Tmem97 and nash

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